Precedes Effector Th Cell Development Cutting Edge: Induction of Follicular Homing

Cutting Edge: Induction of Follicular Homing

Receptor Dependence by Mucosal Effector B Cutting Edge: Dichotomy of Homing

Ultimate Effector Differentiation Helper T Cell Program but Cannot Complete Antigen Presentation Initiates the Follicular Cutting Edge: Dendritic Cell-Restricted

Cutting Edge Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns

Tissue-specific homing of effector and memory T cells to skin and small intestine requires the imprinting of specific combinations of adhesion molecules and chemokine receptors by dendritic cells in the draining lymph nodes. In this study, we demonstrate that CD8 T cells activated by Ag-pulsed bone marrow-derived dendritic cells were induced to express the small intestine homing receptors 4 7 i...

Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development.

T follicular helper (T(FH)) cells are central to the development and regulation of T cell-dependent humoral immune responses. The transcriptional repressor BCL6 is required for T(FH) responses, but the kinetics of BCL6 protein expression in activated CD4(+) T cells have not been established. We measured BCL6 expression during T(FH) cell development at the single-cell level using intracellular s...